Tenofovir Alafenamide Fumarate ：Buy 99% Purity powder Tenofovir Alafenamide Fumarate with good quality Cas: 379270-37-8

Chemical Name: Tenofovir Alafenamide Fumarate

CAS Number: 379270-37-8

Molecular Formula: C19H30N5O10P·C4H4O4

Molecular Weight: 637.55 g/mol

Appearance: White to off-white crystalline powder

Solubility: Slightly soluble in water

Storage Conditions: Store in a cool, dry place, protected from light and moisture.

What is Tenofovir Alafenamide Fumarate?

Tenofovir Alafenamide Fumarate (GS-7340) is an antiviral medication classified as a nucleotide reverse transcriptase inhibitor (NRTI). It is a derivative of Tenofovir, chemically modified to be converted into its active form in the body. This active form effectively inhibits the replication of HIV and hepatitis B viruses. As a long-term treatment for HIV infection and chronic hepatitis B, Tenofovir Alafenamide offers good resistance to drug resistance and has fewer side effects.

Actions and Applications of Tenofovir Alafenamide Fumarate

Anti-HIV Action:

As an anti-HIV drug, Tenofovir Alafenamide Fumarate is an effective reverse transcriptase inhibitor. It suppresses the replication of HIV, reducing viral load, improving immune function, and delaying the progression of AIDS. It is often used in combination with other anti-HIV drugs as part of antiviral therapy.

Anti-Hepatitis B Action:

Tenofovir Alafenamide Fumarate is also used in the treatment of chronic hepatitis B (HBV). By inhibiting the replication of the hepatitis B virus, it reduces viral load, helps decrease liver damage, and improves liver function, thus preventing cirrhosis and liver cancer.

Lower Renal and Bone Toxicity:

Compared to Tenofovir, Tenofovir Alafenamide has lower renal and bone toxicity, as its conversion process in the body reduces the strain on the kidneys. This makes it a safer long-term treatment option, especially for patients who require long-term therapy.

Delayed Virus Resistance:

Tenofovir Alafenamide Fumarate has shown a lower risk of virus resistance in clinical studies, especially in long-term use, making it one of the preferred drugs for treating chronic HIV and hepatitis B.

Combination Therapy:

Tenofovir Alafenamide Fumarate is commonly used in combination with other anti-HIV drugs to enhance treatment efficacy. This combination not only improves effectiveness but also reduces the likelihood of resistance to a single drug, providing more comprehensive antiviral protection.

Safety and Side Effects

The side effects of Tenofovir Alafenamide Fumarate are relatively mild, but some patients may experience mild gastrointestinal discomfort, headaches, and fatigue. Although it has fewer kidney and bone-related side effects compared to traditional Tenofovir, regular monitoring of kidney function and bone density is still recommended, especially for long-term users.

Summary

Tenofovir Alafenamide Fumarate (GS-7340) is an efficient antiviral drug widely used in the treatment of HIV infection and hepatitis B. It demonstrates superior safety in terms of kidney and bone side effects compared to traditional Tenofovir, making it suitable for long-term treatment.