Tacrolimus FK-506：Factory direct supply Top quality Tacrolimus FK-506 powder safe shipping Cas: 104987-11-3

Chemical Name: Tacrolimus

CAS Number: 104987-11-3

Molecular Formula: C44H69NO12

Molecular Weight: 804.03 g/mol

Appearance: Colorless to pale yellow crystalline powder

Solubility: Slightly soluble in water, readily soluble in organic solvents such as ethanol and acetone

Storage Conditions: Store in a cool, dry place, away from light

What is Tacrolimus (FK-506)?

Tacrolimus (FK-506) is a potent immunosuppressant initially derived from a type of actinobacteria. It belongs to the class of immunosuppressive drugs, primarily used to prevent organ rejection after transplantation. Tacrolimus works by inhibiting the immune system's activity, reducing the immune cells' attack on transplanted organs, and helping to maintain the long-term survival of the organs.

Tacrolimus (FK-506) Actions and Applications

Organ Transplantation Applications:
Tacrolimus is primarily used to prevent organ rejection after transplants. It is commonly used in kidney, liver, and heart transplant patients to suppress immune responses, reduce the risk of rejection, and ensure the long-term survival of the transplanted organs.

Treatment of Autoimmune Diseases:
Tacrolimus is also used to treat certain autoimmune diseases where the immune system is overactive, such as rheumatoid arthritis, lupus, and skin diseases. By suppressing the immune system, Tacrolimus can help alleviate symptoms and control these conditions.

Treatment of Skin Diseases:
Topical Tacrolimus ointment is used to treat conditions such as atopic dermatitis (eczema), especially when conventional treatments fail. It works by reducing skin inflammation and relieving itching and redness through local application.

Immunosuppressive Effect:
Tacrolimus exerts its immunosuppressive action by binding to calcineurin, inhibiting T-cell activation, and reducing immune responses. This mechanism is crucial in the treatment of organ transplants, immune diseases, and skin conditions.

Safety and Side Effects

Tacrolimus may cause side effects such as kidney damage, hyperglycemia, increased blood pressure, neurological issues (e.g., tremors and headaches), and increased risk of infections. Therefore, regular monitoring of kidney function, blood sugar, and blood pressure is required when using Tacrolimus. Due to its immunosuppressive effect, users should avoid infections.

Summary
Tacrolimus (FK-506) is a potent immunosuppressant widely used in preventing organ rejection after transplantation and treating autoimmune diseases. By suppressing excessive immune responses, Tacrolimus plays a significant role in maintaining organ transplant survival and alleviating immune system disorders. Careful monitoring of potential side effects is essential to ensure the drug's safety and effectiveness.